Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products
Journal of Medicinal Chemistry2010Vol. 53(14), pp. 5356–5360
Citations Over TimeTop 12% of 2010 papers
Shintaro Suzuki, Emiko Urano, Chie Hashimoto, Hiroshi Tsutsumi, Toru Nakahara, Tomohiro Tanaka, Yuta Nakanishi, Kasthuraiah Maddali, Yan Han, Makiko Hamatake, Kosuke Miyauchi, Yves Pommier, John A. Beutler, Wataru Sugiura, Hideyoshi Fuji, Tyuji Hoshino, Kyoko Itotani, Wataru Nomura, Tetsuo Narumi, Naoki Yamamoto, Jun Komano, Hirokazu Tamamura
Abstract
Anti-HIV peptides with inhibitory activity against HIV-1 integrase (IN) have been found in overlapping peptide libraries derived from HIV-1 gene products. In a strand transfer assay using IN, inhibitory active peptides with certain sequential motifs related to Vpr- and Env-derived peptides were found. The addition of an octa-arginyl group to the inhibitory peptides caused a remarkable inhibition of the strand transfer and 3'-end-processing reactions catalyzed by IN and significant inhibition against HIV replication.
Related Papers
- Characterization and structural analysis of HIV-1 integrase conservation.(2009)
- → Evolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy(2010)73 cited
- → Integrase inhibitors in the treatment of HIV-1 infection(2010)56 cited
- → Synthesis and HIV-1 Integrase Inhibition Activity of some N-Arylindoles(2008)46 cited
- Synthesis and HIV integrase inhibitory activity of caffeic acid derivatives(2005)