Synthesis and Biological Evaluation of Novel Thiazolidinedione Analogues as 15-Hydroxyprostaglandin Dehydrogenase Inhibitors
Journal of Medicinal Chemistry2011Vol. 54(14), pp. 5260–5264
Citations Over TimeTop 10% of 2011 papers
Ying Wu, Sandeep Karna, Cheol Hee Choi, Min Tong, Hsin‐Hsiung Tai, Dong Hee Na, Chul Ho Jang, Hoon Cho
Abstract
Novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors were synthesized. Compounds 2, 3, and 4 exhibited IC(50) of 25, 8, and 19 nM, respectively. They also significantly increased levels of PGE(2) in A549 cells. To assess the influence of 15-PGDH inhibitor on cochlear blood flow (CBF), 2 was applied intravenously to guinea pigs. It increased their CBFs. Scratch wounds were also analyzed in confluent monolayers of HaCaT cells. Cells exposed to 4 showed significantly improved wound healing with respect to a control.
Related Papers
- Anti-oxidative Effects of Taraxaci Herba and Protective Effects on Human HaCaT Keratinocyte(2009)
- → UV induced responses of the human epidermal IGF system: Impaired anti-apoptotic effects of IGF-I in HaCaT keratinocytes(2005)8 cited
- The protective effect of astaxanthin on HaCaT keratinocytes injured by oxidative stress(2013)
- → Protective Effect of Processed Saengmaek-san(SM) on Cell Damage in UV-exposed HaCaT Cell(2011)
- → Antioxidative Effect of Phellinus Igniarius Polysaccharide on HaCaT Cells Based on Multi-parameter Analysis by AFM Imaging(2022)