Synthesis and Structure–Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase
Journal of Medicinal Chemistry2013Vol. 56(4), pp. 1777–1781
Citations Over TimeTop 12% of 2013 papers
Karin Meirer, Carmen B. Rödl, Joanna Wiśniewska, Sven George, Ann‐Kathrin Häfner, Estel·la Buscató, Franca‐Maria Klingler, Steffen Hahn, Dirk Berressem, Sandra K. Wittmann, Dieter Steinhilber, Bettina Hofmann, Ewgenij Proschak
Abstract
Current research leads to the assumption that drugs affecting more than one target could result in a more efficient treatment of diseases and fewer safety concerns. Administration of drugs inhibiting only one branch of the arachidonic acid cascade is usually accompanied by side effects. We therefore designed and synthesized a library of hybrid molecules incorporating an imidazo[1,2-a]pyridine and an urea moiety as novel soluble epoxide hydrolase (sEH)/5-lipoxygenase (5-LO) dual inhibitors. Evaluation of the compounds was accomplished by in vitro testing using recombinant enzyme assays.
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