Organometallic Nucleoside Analogues with Ferrocenyl Linker Groups: Synthesis and Cancer Cell Line Studies
Journal of Medicinal Chemistry2014Vol. 57(13), pp. 5817–5822
Citations Over TimeTop 10% of 2014 papers
Huy V. Nguyen, Antoine Sallustrau, Jan Balzarini, Matthew Bedford, John C. Eden, Niki Georgousi, Nikolas J. Hodges, Jonathan L. Kedge, Youcef Mehellou, Chris Tselepis, James H. R. Tucker
Abstract
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
Related Papers
- → Preparation and characterisation of C60(ferrocene)2(1992)169 cited
- → Möissbauer Study of Fullerene (Ferrocene)2and Decamethyl-Ferrocene(1997)11 cited
- → Syntheses and Characterization of 1,1'-Bis(3-Pyridylethynyl)Ferrocene and 1,1'-Bis(4-Pyridylethynyl)Ferrocene(2001)10 cited
- → Pair Formation of Free Nucleobases and Mononucleosides in the Gas Phase(1994)14 cited
- Type of Ferrocenes on Sensitivities of Ultra-fine AP and Ferrocene Mixture(2011)