Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring
Citations Over TimeTop 10% of 2014 papers
Abstract
Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell proliferation, metabolism, migration, survival, and responses to diverse stresses including DNA damage. To design novel efficient strategies for treatment of cancer and other diseases, these kinases have been extensively studied. Despite their different nature, these two kinase families have related origin and share very similar kinase domains. Therefore, chemical inhibitors of these kinases usually carry analogous structural motifs. The most common feature of these inhibitors is a critical hydrogen bond to morpholine oxygen, initially present in the early nonspecific PI3K and PIKK inhibitor 3 (LY294002), which served as a valuable chemical tool for development of many additional PI3K and PIKK inhibitors. While several PI3K pathway inhibitors have recently shown promising clinical responses, inhibitors of the DNA damage-related PIKKs remain thus far largely in preclinical development.
Related Papers
- → Pathways for phosphoinositide synthesis(1999)86 cited
- → A homogeneous and nonisotopic assay for phosphatidylinositol 4-kinases(2011)61 cited
- Phosphatidylinositol phosphate kinases.(2004)
- → Phosphoinositide breakdown in blowfly salivary glands(1984)23 cited
- → Effect of Progesterone on the Stimulation of Phosphatidylinositol Turnover by Epinephrine in Guinea Pig Ductus Deferens(1989)