Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
Journal of Medicinal Chemistry2008Vol. 51(3), pp. 347–372
Citations Over TimeTop 1% of 2008 papers
Andrea Cavalli, María Laura Bolognesi, Anna Minarini, Michela Rosini, Vincenzo Tumiatti, Maurizio Recanatini, Carlo Melchiorre
Abstract
A review. The authors review the investigations reported in the past decade that illustrate the ability of medicinal chemists to design multi-target-directed ligands (MTDLs) to confront neurodegenerative diseases. The authors briefly illustrate the multifactorial nature of these diseases before discussing the possible development of MTDLs in light of the known mol. bases of the main neurodegenerative pathologies.
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