Discovery of a Tetrazole-Based Growth Hormone Secretagogue: 4-(Hydroxybutyl)carbamic Acid 2-{5-[1-(2-Amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl Ester (BMS-317180)
Journal of Medicinal Chemistry2007Vol. 50(24), pp. 5890–5893
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Jun Li, Stephanie Chen, James J. Li, Haixia Wang, Andrés S. Hernández, Shiwei Tao, Christa M. Musial, Fucheng Qu, Stephen G. Swartz, Sam Chao, Neil Flynn, Brian J. Murphy, Dorothy Slusarchyk, Ramakrishna Seethala, Mujing Yan, Paul G. Sleph, Gary J. Grover, Mark A. Smith, Blake C. Beehler, Leah Giupponi, Kenneth E.J. Dickinson, Hongjian Zhang, W. Griffith Humphreys, Bharat Patel, Mark D. Schwinden, Terry R. Stouch, Peter T. W. Cheng, Scott A. Biller, William R. Ewing, David Gordon, Jeffrey A. Robl, Joseph A. Tino
Abstract
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.
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