Design, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid
Journal of Medicinal Chemistry2008Vol. 51(15), pp. 4834–4838
Citations Over TimeTop 13% of 2008 papers
Li Chen, Yihua Zhang, Xiangwen Kong, Edward Lan, Zhangjian Huang, Sixun Peng, Daniel L. Kaufman, Jide Tian
Abstract
Novel furoxan-based nitric oxide (NO) releasing derivatives of oleanolic acid (OA) were synthesized for potential therapy of liver cancers. Six compounds produced high levels of NO in human hepatocellular carcinoma (HCC) cells and exhibited strong cytotoxicity selectively against HCC in vitro. Treatment with 8b or 16b significantly inhibited the growth of HCC tumors in vivo. These data provide a proof-in-principle that furoxan/OA hybrids may be used for therapeutic intervention of human liver cancers.
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