Potential Nicotinic Acetylcholine Receptor Ligands from 2,4-Methanoproline Derivatives
Journal of Medicinal Chemistry2008Vol. 51(21), pp. 7005–7009
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Abstract
Potential nicotinic acetylcholine receptor (nAChR) ligands have been synthesized in which a methylisoxazole substituent is attached to the 1-position ( 26) of the 2-azabicyclo[2.1.1]hexane ring system or separated by "spacer" atoms ( 21 and 23). With ABT-594 as a model, a range of pyridine heterocycles have been attached to the 1-position via a -CH 2O- spacer ( 11, 14, and 6). The biological evaluation of target compounds showed there was no binding affinity at the alpha4beta2 and alpha3beta4 nAChR subtypes.
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