Target Flexibility: An Emerging Consideration in Drug Discovery and Design

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Abstract

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTTarget Flexibility: An Emerging Consideration in Drug Discovery and Design†Pietro Cozzini*‡§, Glen E. Kellogg*#, Francesca Spyrakis‡§, Donald J. Abraham‡, Gabriele Costantino∥, Andrew Emerson⊥, Francesca Fanelli∞, Holger Gohlke×, Leslie A. Kuhn¶, Garrett M. Morris●, Modesto Orozco◇, Thelma A. Pertinhez◆, Menico Rizzi∇, and Christoph A. Sotriffer⊗View Author Information Department of General and Inorganic Chemistry, University of Parma, Via G.P. Usberti 17/A 43100, Parma, Italy, National Institute for Biosystems and Biostructures, Rome, Italy, Department of Medicinal Chemistry and Institute for Structural Biology & Drug Discovery, Virginia Commonwealth University, Richmond, Virginia 23298-0540, Department of Pharmaceutics, University of Parma, Via GP Usberti 27/A, 43100 Parma, Italy, High Performance Systems, CINECA Supercomputing Centre, Casalecchio di Reno, Bologna, Italy, Dulbecco Telethon Institute, Department of Chemistry, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy, Department of Mathematics and Natural Sciences, Pharmaceutical Institute, Christian-Albrechts-University, Gutenbergstrasse 76, 24118 Kiel, Germany, Departments of Biochemistry & Molecular Biology, Computer Science & Engineering, and Physics & Astronomy, Michigan State University, East Lansing, Michigan 48824-1319, Department of Molecular Biology, MB-5, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037-1000, Molecular Modeling and Bioinformatics Unit, Institute of Biomedical Research, Scientific Park of Barcelona, Department of Biochemistry and Molecular Biology, University of Barcelona, Josep Samitier 1-5, Barcelona 08028, Spain, Department of Experimental Medicine, University of Parma, Via Volturno, 39, 43100, Parma, Italy, Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences, University of Piemonte Orientale "Amedeo Avogadro", Via Bovio 6, 28100 Novara, Italy, Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany†Consensus report of "From Structural Genomics to Drug Discovery: Modeling the Flexibility", September 20−21, 2007, Parma, Italy. International course and report were conceived by Pietro Cozzini and Glen E. Kellogg.* To whom correspondence should be addressed. For P.C.: (address) Department of General and Inorganic Chemistry, University of Parma, Via G.P. Usberti 17/A 43100, Parma, Italy; (phone) +39-0521-905669; (fax) +39-0521-905556; (e-mail) [email protected]. For G.E.K.: (address) Department of Medicinal Chemistry, Virginia Commonwealth University, Box 980540, Richmond, VA 23298-0540; (phone) 804-828-6452; (fax) 804-827-3664; (e-mail) [email protected]‡Department of General and Inorganic Chemistry, University of Parma.§National Institute for Biosystems and Biostructures.#Virginia Commonwealth University.∥Department of Pharmaceutics, University of Parma.⊥CINECA Supercomputing Centre.∞University of Modena and Reggio Emilia.×Christian-Albrechts-University.¶Michigan State University.●The Scripps Research Institute.◇University of Barcelona.◆Department of Experimental Medicine, University of Parma.∇University of Piemonte Orientale "Amedeo Avogadro".⊗University of Würzburg.Cite this: J. Med. Chem. 2008, 51, 20, 6237–6255Publication Date (Web):September 12, 2008Publication History Received14 May 2008Published online12 September 2008Published inissue 23 October 2008https://pubs.acs.org/doi/10.1021/jm800562dhttps://doi.org/10.1021/jm800562dreview-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views4958Altmetric-Citations241LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Conformation,Ligands,Molecular structure,Protein structure,Receptors Get e-Alerts

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