Structure−Activity Relationship of New Anti-Hepatitis C Virus Agents: Heterobicycle−Coumarin Conjugates
Journal of Medicinal Chemistry2009Vol. 52(5), pp. 1486–1490
Citations Over TimeTop 10% of 2009 papers
Johan Neyts, Erik De Clercq, Raghunath Singha, Yung Chang, Asish R. Das, Subhasish Chakraborty, Shih Ching Hong, Shwu‐Chen Tsay, Ming‐Hua Hsu, Jih Ru Hwu
Abstract
For establishment of the structure-activity relationship, 19 heterobicycle-coumarin conjugated compounds with the -SCH(2)- linker were synthesized and found to possess significant antiviral activities. Prominent examples included imidazopyridine-coumarin 12c, purine-coumarin 12d, and benzoxazole-coumarin 14c, which inhibited HCV replication at an EC(50) of 6.8, 2.0, and 12 microM, respectively. The heteroatoms in bicycles and the substituent effect on coumarin played essential roles.
Related Papers
- → A new method of synthesis of some 2‐aryl and 2‐heterocyclic benzimidazole, benzoxazole and benzothiazole derivatives(1979)38 cited
- → Reaction of the 2-(bromodifluoromethyl)benzoxazole with tetrakis(dimethylamino)ethylene (TDAE) in the presence of aldehydes. A convenient synthesis of 2-(difluoromethyl)benzoxazole alcohols(1997)28 cited
- Design, synthesis and screening of some novel benzoxazole based 1,3,4-oxadiazoles as potential antimicrobial agents(2013)
- → Cyanoacetylenes in a reaction with benzoxazole-2-thione and benzoxazol-2-one(1990)1 cited
- A Density Functional Theory Study on the Substituent Electronic Effects in Intramolecular Proton Transfer of 2-(2-Mercaptophenyl)benzoxazole(2010)