Synthesis of Acyclo-C-nucleosides in the Imidazo[1,2-a]pyridine and Pyrimidine Series as Antiviral Agents
Journal of Medicinal Chemistry1996Vol. 39(14), pp. 2856–2859
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Alain Gueiffier, Mohammed Lhassani, Ahmed Elhakmaoui, Robert Snoeck, Graciela Andreï, Olivier Chavignon, Jean‐Claude Teulade, Abdelali Kerbal, El Mokhtar Essassi, Jean‐Claude Debouzy, Myriam Witvrouw, Yves Blache, Jan Balzarini, Erik De Clercq, Jean‐Pierre Chapat
Abstract
The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.
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