A Facile, Alternative Synthesis of 4‘-Thioarabinonucleosides and Their Biological Activities
Journal of Medicinal Chemistry1997Vol. 40(14), pp. 2177–2183
Citations Over TimeTop 10% of 1997 papers
Yuichi Yoshimura, Mikari Watanabe, Hiroshi Satoh, Noriyuki Ashida, Katsushi Ijichi, Shinji Sakata, Haruhiko Machida, Akira Matsuda
Abstract
4'-Thioarabinonucleosides, which are potential antiviral agents, were synthesized from D-glucose. 1,4-Anhydro-4-thioarabitol (8), which can be derived from diacetone glucose in nine steps, was subjected to Pummerer rearrangement after protection of the hydroxyl groups to give 1-O-acetyl-4-thioarabinose (11), which was condensed with nucleobases to give 4'-thioarabinonucleosides. The 5-substituted-4'-thioaraU (6a-e) derivatives showed anti-HSV-1 activity (ED50 = 0.43-3.50 micrograms/mL). 4'-ThioaraG (6h) and 2,6-diaminopurine 4'-thioarabinonucleoside (4'-thioaraDAP, 6g) showed antiviral activity against several herpes viruses and were particularly potent against human cytomegalovirus (0.010 and 0.022 microgram/mL, respectively).
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