Isoxazolidine-3,5-dione and Noncyclic 1,3-Dicarbonyl Compounds as Hypoglycemic Agents
Journal of Medicinal Chemistry1998Vol. 41(11), pp. 1927–1933
Citations Over TimeTop 10% of 1998 papers
Hisashi Shinkai, Syoji Onogi, Masahiro Tanaka, Tsutomu Shibata, Megumi Iwao, Korekiyo Wakitani, Itsuo Uchida
Abstract
Isoxazolidine-3,5-dione 2 (JTT-501), one of the cyclic malonic acid derivatives, was found to decrease blood glucose at an oral dose of 38 mg/kg/day in KKAy mice and is currently undergoing evaluation in phase II clinical trials. Further studies on a series of malonic acids and related compounds showed that the 1,3-dicarbonyl structure was important for insulin-sensitizing activity. Dimethyl malonate 10, which was selected as a successor for 2, was the optimum compound in a series of 1,3-dicarbonyl compounds and was more potent than the corresponding thiazolidine-2,4-dione 1.
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