Antimalarial, Antiproliferative, and Antitumor Activities of Artemisinin-Derived, Chemically Robust, Trioxane Dimers
Journal of Medicinal Chemistry1999Vol. 42(21), pp. 4275–4280
Citations Over TimeTop 10% of 1999 papers
Gary H. Posner, Poonsakdi Ploypradith, Michael H. Parker, Hardwin O’Dowd, Soon-Hyung Woo, John Northrop, Mikhail Krasavin, Patrick Dolan, Thomas W. Kensler, Suji Xie, Theresa A. Shapiro
Abstract
Nine C-10 non-acetal derivatives of the natural trioxane artemisinin (1) were prepared as dimers using some novel chemistry. As designed, each dimer was stable chemically. C-10 Olefinic dimers 7 and C-10 saturated dimers 8-13 all showed good to excellent antimalarial and antiproliferative activities in vitro. Dimers 8, 10, and 12 were especially potent and selective at inhibiting growth of some human cancer cell lines in the NCI in vitro 60-cell line assay.
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