First Synthesis of Totally Orthogonal Protected α-(Trifluoromethyl)- and α-(Difluoromethyl)arginines
The Journal of Organic Chemistry2000Vol. 66(1), pp. 130–133
Citations Over TimeTop 19% of 2000 papers
Maurizio Moroni, Beate Koksch, Sergey N. Osipov, Marcello Crucianelli, Massimo Frigerio, Pierfrancesco Bravo, Klaus Burger
Abstract
The first synthesis of a series of totally orthogonal protected racemic alpha-(trifluoromethyl)- and alpha-(difluoromethyl)arginines is described. The key steps of the synthesis are the mild guanidinylation procedure and the selective hydrogenation of a CC triple bond in the presence of a Cbz-group.
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