Regioselective Synthesis of Polysubstituted Pyrazoles and Isoxazoles
The Journal of Organic Chemistry2001Vol. 66(20), pp. 6787–6791
Citations Over TimeTop 10% of 2001 papers
Abstract
A regioselective synthesis has been developed for the preparation of unsymmetrical 1,3,5-triaryl-4-alkylpyrazolines and -pyrazoles by treatment of alpha-benzotriazolyl-alpha,beta-unsaturated ketones with monosubstituted hydrazines followed by alkylation at the 4-position of the pyrazoline ring. Reaction of alpha-benzotriazolyl-alpha,beta-unsaturated ketones with hydroxylamine gives 3,5-disubstituted isoxazoles regioselectively.
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