Catalytic Leuckart−Wallach-Type Reductive Amination of Ketones
The Journal of Organic Chemistry2002Vol. 67(24), pp. 8685–8687
Citations Over TimeTop 16% of 2002 papers
Abstract
A CpRh(III) complex catalyzes reductive amination of ketones using HCOONH(4) at 50-70 degrees C to give the corresponding primary amines in high yields. The reaction is clean and operationally simple and proceeds at a lower temperature and with higher chemoselectivity than the original Leuckart-Wallach reaction. The new method has been applied to the synthesis of alpha-amino acids directly from alpha-keto acids.
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