Crowned Dendrimers: pH-Responsive Pseudorotaxane Formation
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Abstract
With the end goal of incorporating the unique structural and physical properties of dendrimers into supramolecular assemblies, bis(m-phenylene)-32-crown-10-functionalized poly(propyleneimine) dendrimers of the first and third generations have been synthesized and their interaction with paraquat diol has been investigated. Using (1)H NMR, we determined that binding to the 4 or 16 crown ether sites occurred in an anti-cooperative fashion, most likely a result of steric influences. Upon protonation of the tertiary amines in the dendritic interior, binding became independent, i.e., statistical, and the average apparent association constant increased by nearly 5-fold; this effect is attributed to rigidification of the dendrimer, which makes its binding sites more accessible and less crowded.
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