Dictyodendrins A−E, the First Telomerase-Inhibitory Marine Natural Products from the Sponge Dictyodendrilla verongiformis1
The Journal of Organic Chemistry2003Vol. 68(7), pp. 2765–2770
Citations Over TimeTop 10% of 2003 papers
Abstract
Five new alkaloids, dictyodendrins A-E (1-5), were isolated from the Japanese marine sponge Dictyodendrilla verongiformis as telomerase inhibitors. Their structures were elucidated by spectroscopic and chemical methods. Dictyodendrins are tyramine-based pyrrolocarbazole derivatives containing three or four p-hydroxybenzene groups. They inhibited telomerase completely at a concentration of 50 microg/mL.
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