Early Amidation Approach to 3-[(4-Amido)pyrrol-2-yl]-2-indolinones
The Journal of Organic Chemistry2003Vol. 68(16), pp. 6447–6450
Citations Over TimeTop 22% of 2003 papers
Jerad M. Manley, Monica Kalman, Brian G. Conway, Cynthia C. Ball, Jeffrey L. Havens, Rajappa Vaidyanathan
Abstract
A new synthesis of 3-[(4-amido)pyrrol-2-yl]-2-indolinones has been developed, where the amide side chain was installed prior to pyrrole formation. This strategy precludes the need to use any coupling reagents to install the amide side chain. This process includes a zinc-free alternative to the Knorr pyrrole synthesis.
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