B-Alkyl Suzuki−Miyaura Cross-Coupling Reactions with Air-Stable Potassium Alkyltrifluoroborates
The Journal of Organic Chemistry2003Vol. 68(14), pp. 5534–5539
Citations Over TimeTop 10% of 2003 papers
Abstract
The palladium-catalyzed cross-coupling reaction of substituted potassium alkyltrifluoroborates with aryl halides and aryl triflates proceeds readily with moderate to good yields. The potassium alkyltrifluoroborates 1, 2, and 3a−e were easily synthesized and obtained as air-stable crystalline solids that can be stored for long periods of time. All of the cross-couplings proceed under the same reaction conditions using PdCl2(dppf)·CH2Cl2 as catalyst in THF−H2O in the presence of 3 equiv of Cs2CO3 as base.
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