A Novel Method for the Preparation of α,α‘-Difluoroesters and Acids Using BrF3
The Journal of Organic Chemistry2003Vol. 68(21), pp. 8287–8289
Citations Over TimeTop 11% of 2003 papers
Abstract
Alkyl-, haloalkyl-, and ketoalkyl-2-ethoxycarbonyl-1,3-dithianes were easily made from the appropriate primary or secondary alkyl bromides, 1,3-dithiane, and ethyl chloroformate. They were reacted with BrF(3) to form the corresponding alpha,alpha-difluoro esters in 65-75% yield. Reaction conditions are very mild (1-2 min, 0 degrees C). The two sulfur atoms of the dithiane are essential for the reaction.
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