Highly Efficient aza-Baylis−Hillman Reaction of N-Tosylated Imines with MVK, Acrolein, and Phenyl Acrylate or α-Naphthyl Acrylate: Lewis Base Effects and A Convenient Method to Synthesize α,β-Unsaturated β-Amino Carbonyl Compounds

Citations Over TimeTop 10% of 2003 papers

Abstract

This paper describes several highly efficient aza-Baylis-Hillman reactions of N-tosylated imines with MVK, acrolein, and phenyl acrylate or alpha-naphthyl acrylate in the presence of a Lewis base. In most cases, the reaction can be completed within 1 h using the appropriate Lewis base catalyst. An efficient method to synthesize beta-amino ketones, aldehydes and esters in high yields and short reaction time has been developed.

Related Papers

• → The Use of DMAP as Catalyst in the Baylis-Hillman Reaction Between Methyl Acrylate and Aromatic Aldehydes(2003)38 cited
• → Baylis–Hillman reactions of N-arylidenediphenylphosphinamides with methyl vinyl ketone, methyl acrylate, and acrylonitrile(2002)33 cited
• → Reexamination of the traditional Baylis–Hillman reaction(2003)24 cited
• Transformation of CO_2 and Ethylene to Methyl Acrylate With Molybdenum Complexes as Catalyst(2015)
• → Baylis—Hillman Reactions of N‐Arylidenediphenylphosphinamides with Methyl Vinyl Ketone, Methyl Acrylate, and Acrylonitrile.(2002)