Synthesis of Alkylated Aminofluorenes by Palladium-Catalyzed Substitution at Halofluorenes
The Journal of Organic Chemistry2004Vol. 69(3), pp. 987–990
Citations Over TimeTop 19% of 2004 papers
Abstract
New N-substituted 2-amino-9,9-dialkylfluorenes optionally bearing electron-withdrawing substituents such as nitro or cyano in position 7 can be synthesized starting from 2-halo-9,9-dialkylfluorenes by Pd-catalyzed substitution with amines. Chiral amino groups can be introduced by this method too. 2-N,N-Dimethylamino-7-nitro-9H-fluorene was obtained in a convenient way by reductive amination. The N-substituted 2-amino-7-nitro-9H-fluorenes are promising candidates for fluorescence probes for femtosecond solvation dynamics.
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