Reactions on a Solid Surface. A Simple, Economical, and Efficient Acylation of Alcohols and Amines over Al2O3
The Journal of Organic Chemistry2003Vol. 69(2), pp. 577–580
Citations Over TimeTop 12% of 2003 papers
Abstract
Al(2)O(3) brings about a rapid acylation of a range of alcohols and amines with acid chlorides and acid anhydrides, respectively. Amines are easily Boc- and Cbz-protected on reaction with Boc-anhydride and Cbz-Cl, respectively. The acylation of phenols is slow enough to allow chemoselective acylation of alcohols and amines in the presence of phenols.
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