N-Amination of Pyrrole and Indole Heterocycles with Monochloramine (NH2Cl)
The Journal of Organic Chemistry2004Vol. 69(4), pp. 1368–1371
Citations Over TimeTop 10% of 2004 papers
John Hynes, Wendel W. Doubleday, Alaric J. Dyckman, Jollie D. Godfrey, John A. Grosso, Susanne Kiau, Katerina Leftheris
Abstract
A survey of several electrophilic ammonia reagents for the N-amination of indole- and pyrrole-containing heterocycles revealed that monochloramine (NH(2)Cl) is an excellent reagent for this transformation. Pyrroles and indoles containing a variety of substitution were aminated on nitrogen with isolated yields ranging from 45% to 97%.
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