Ligand-Free Palladium-Catalyzed Cyanation of Aryl Halides
The Journal of Organic Chemistry2005Vol. 70(4), pp. 1508–1510
Citations Over TimeTop 10% of 2005 papers
Abstract
[reaction: see text] A practical, ligand-free cyanation of aryl bromides that utilizes as little as 0.1 mol % Pd(OAc)(2) in combination with a nontoxic cyanide source, M(4)[Fe(CN)(6)] (M = K, Na), is described. The reactions are performed in DMAC at 120 degrees C and provide the corresponding aryl nitrile in 83-96% yield, typically in less than 5 h. TON values of up to 7100 were attained.
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