A Concise Synthesis of a Novel Antiangiogenic Tyrosine Kinase Inhibitor
The Journal of Organic Chemistry2004Vol. 70(1), pp. 175–178
Citations Over TimeTop 10% of 2004 papers
Abstract
An efficient synthesis of the potent KDR inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indole-2-yl]quinolin-2(1H)-one (1) is described. The process features a noncryogenic indole boronation and a dicyclohexylamine-mediated Suzuki coupling.
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