Highly Enantioselective Cyanosilylation of Aldehydes Catalyzed by Novel β-Amino Alcohol−Titanium Complexes
The Journal of Organic Chemistry2004Vol. 69(23), pp. 7910–7913
Citations Over TimeTop 10% of 2004 papers
Abstract
The beta-amino alcohol 1b-Ti(Oi-Pr)(4) complex has been shown to catalyze the enantioselective cyanosilylation of aldehydes efficiently. In the presence of 5 mol % of 1b-Ti(Oi-Pr)(4) complex catalyst, the aromatic, conjugated, heteroaromatic, and aliphatic aldehydes were converted to their corresponding trimethylsilyl ethers of cyanohydrins in 90-99% yields with up to 94% ee under mild conditions.
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