Me2Zn-Mediated Addition of Acetylenes to Aldehydes and Ketones
The Journal of Organic Chemistry2005Vol. 70(14), pp. 5733–5736
Citations Over TimeTop 10% of 2005 papers
Abstract
[reaction: see text] Contrary to expectations, commercially available 2 M Me2Zn in toluene is able to promote the addition of phenylacetylene to aldehydes and ketones. This reactivity is determined by a new, unprecedented mechanism, which involves activation of the zinc reagent via coordination with carbonyl substrates that behave "ligand like". Broad scope, high tolerance to functional groups, and a simple procedure make this new method highly interesting for the synthetic chemist.
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