Copper- and Ligand-Free Sonogashira Reaction Catalyzed by Pd(0) Nanoparticles at Ambient Conditions under Ultrasound Irradiation
The Journal of Organic Chemistry2005Vol. 70(12), pp. 4869–4872
Citations Over TimeTop 1% of 2005 papers
Atul R. Gholap, K. Venkatesan, Renu Pasricha, Thomas Daniel, Rajgopal J. Lahoti, Kumar V. Srinivasan
Abstract
The Sonogashira reaction proceeds at ambient temperature (30 degrees C) in acetone or room-temperature ionic liquid, 1,3-di-n-butylimidazolium tetrafluoroborate ([bbim]BF4), as solvent under ultrasound irradiation to give enhanced reaction rates, excellent chemoselectivity, and high yields in the absence of a copper cocatalyst and a phosphine ligand. TEM analysis showed the formation of stable, crystalline, and polydispersed Pd(0) nanoparticles as catalyst for the reaction.
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