Preparation and Synthetic Application of a Novel Ketene Silyl Acetal of Methyl Trifluoropyruvate
The Journal of Organic Chemistry2005Vol. 70(22), pp. 8811–8816
Citations Over TimeTop 19% of 2005 papers
Abstract
[reaction: see text] A novel trifluoromethyl ketene silyl acetal (4) of methyl trifluoropyruvate (1) was prepared in 82% yield by metal Mg reduction in a (TMS)Cl/THF system. Subsequent carbon-carbon bond formation such as Mukaiyama aldol, Michael addition, and other nucleophilic reactions of 4 at the trifluoromethylated carbon with various electrophiles gave various coupling products in high yields.
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