A Versatile Method for the Synthesis of 3-Alkoxycarbonyl β-Lactam Derivatives
The Journal of Organic Chemistry2005Vol. 71(2), pp. 815–818
Citations Over TimeTop 13% of 2005 papers
Abstract
[reaction: see text] Ketene-imine cycloaddition reactions (the Staudinger reaction) of ethoxycarbonyl(phenylthio)ketene with various imines and subsequent desulfurization reactions were employed to synthesize 3-ethoxycarbonyl beta-lactam derivatives. The results indicate that the current approach provides a convenient, mild, and versatile method for synthesizing a variety of 3-alkoxycarbonyl trans-beta-lactam derivatives with good to excellent yields and diastereoselectivities.
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