Base−Base Interactions in the Minor Groove of Double-Stranded DNA
The Journal of Organic Chemistry2006Vol. 71(15), pp. 5423–5431
Citations Over TimeTop 21% of 2006 papers
Tongfei Wu, Koen Nauwelaerts, Arthur Van Aerschot, Matheus Froeyen, Eveline Lescrinier, Piet Herdewijn
Abstract
A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A-T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.
Related Papers
- → Fluorescent d(CGCGAATTCGCG): characterization of major groove polarity and study of minor groove interactions through a major groove semantophore conjugate(1995)78 cited
- → Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair(2015)24 cited
- → Binding Properties of the Conjugates of Oligo(2′‐O‐Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA(2004)4 cited
- → Binding Properties of the Conjugates of Oligo(2′‐O‐Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA(2005)
- → Conjugates of Oligo(2′‐O‐Methylribonucleotides) with Minor Groove Binders as New Sequence‐Specific Agents Recognizing Both Grooves of Double‐Stranded DNA(2004)