Microwave Assisted “Click” Chemistry for the Synthesis of Multiple Labeled-Carbohydrate Oligonucleotides on Solid Support
The Journal of Organic Chemistry2006Vol. 71(12), pp. 4700–4702
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Camille Bouillon, Albert Meyer, Sébastien Vidal, A.M. Jochum, Yann Chevolot, Jean‐Pierre Cloarec, Jean‐Pierre Praly, Jean‐Jacques Vasseur, F. Morvan
Abstract
A versatile approach has been developed for the multiple labeling of oligonucleotides. First, three linkers as a H-phosphonate monoester derivative were condensed on a solid-supported T12 to introduce H-phosphonate diester linkages which were oxidized in the presence of propargylamine. Second, three galactosyl azide derivatives were conjugated to the solid-supported three-alkyne-modified T12 by a 1,3-cycloaddition so-called "click chemistry" in the presence of Cu(I) assisted by microwaves.
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