Organocatalytic Asymmetric Deconjugative Michael Additions
The Journal of Organic Chemistry2006Vol. 71(14), pp. 5407–5410
Citations Over TimeTop 10% of 2006 papers
Abstract
The organocatalytic allylic C-C bond-forming addition of activated alkylidenes to acrolein has been achieved with good yield and regio- and enantioselectivity. Chiral tertiary amines in the form of cinchona alkaloid catalysts are used to give allyl intermediates that exhibit unusual alpha-selectivity in the C-C bond-forming step. The products are transformed into a large range of intermediates that are difficult to access via alternative methods, using different oxidative and reductive protocols.
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