Phosphine-Free Palladium-Catalyzed C−H Bond Arylation of Free (N−H)-Indoles and Pyrroles
The Journal of Organic Chemistry2007Vol. 72(4), pp. 1476–1479
Citations Over TimeTop 1% of 2007 papers
Abstract
This paper describes a phosphine-free palladium-catalyzed method for direct C-arylation of free (N-H)-indoles and pyrroles with iodo- and bromoarene donors. Employing commercially available materials, this new and operationally simple procedure provides a rapid entry to a wide range of C-arylated (N-H)-indoles including derivatives of tryptamine. In the course of this study, a profound halide effect was uncovered, affecting both the efficiency and regioselectivity of indole arylation.
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