Metal Triflate Catalyzed Reactions of Alkenes, NBS, Nitriles, and TMSN3: Synthesis of 1,5-Disubstituted Tetrazoles
The Journal of Organic Chemistry2007Vol. 72(5), pp. 1852–1855
Citations Over TimeTop 17% of 2007 papers
Abstract
A versatile and highly efficient protocol for the synthesis of 1,5-disubstituted tetrazoles has been developed by metal triflate catalyzed one-pot reaction of alkenes, NBS, nitriles, and TMSN3. Among the metal triflates, Zn(OTf)2 was found to be the best catalyst. Use of different combinations of alkenes and nitriles generate a variety of 1,5-disubstituted tetrazoles containing an additional alpha-bromo functionality of the N1-alkyl substituent.
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