Et2Zn-Catalyzed Intramolecular Hydroamination of Alkynyl Sulfonamides and the Related Tandem Cyclization/Addition Reaction
The Journal of Organic Chemistry2007Vol. 72(15), pp. 5731–5736
Citations Over TimeTop 10% of 2007 papers
Abstract
Intramolecular hydroamination of alkynyl amides was effected by a catalytic amount of Et2Zn (20 mol %) to form indole derivatives, and a tandem cyclization/nucleophilic addition procedure involving reaction of the indole zinc salt intermediate with acid chlorides or halides was developed to provide an efficient approach to C3-substituted indole derivatives when an excess of Et2Zn (120 mol %) was used.
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