A New Asymmetric Synthesis of the Anti-Tumor Alkaloid (R)-(+)-Crispine A
The Journal of Organic Chemistry2007Vol. 72(23), pp. 8972–8975
Citations Over TimeTop 10% of 2007 papers
Steven M. Allin, Sean N. Gaskell, Joannah M. R. Towler, Philip C. Bulman Page, Basudeb Saha, Michael J. McKenzie, William P. Martin
Abstract
We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.
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