Amino Acids as the Nitrogen-Containing Motifs in Copper-Catalyzed Domino Synthesis of N-Heterocycles
The Journal of Organic Chemistry2011Vol. 76(10), pp. 3846–3852
Citations Over TimeTop 10% of 2011 papers
Abstract
A copper-catalyzed domino method for synthesis of quinazolinones has been developed using readily available α-amino acids as the nitrogen-containing motifs. The domino process underwent Ullmann-type N-arylation, decarboxylation, aerobic oxidation, and intramolecular addition. This method should provide a new and useful strategy for construction of N-heterocycles.
Related Papers
- → N‐Heterocyclic Carbene Catalyzed Domino Reactions(2011)979 cited
- → Metal-Free Synthesis of Fully Substituted Pyridines via Ring Construction Based on the Domino Reactions of Enaminones and Aldehydes(2016)71 cited
- → Short and Modular Synthesis of Substituted 2-Aminopyrroles(2021)18 cited
- → 6.13 C–C Bond Formation: Cascade or Domino Reaction(2012)7 cited
- → Inside Cover: Formation of 2‐Acyloxazoles by a Multipathway Coupled Domino Strategy: One‐Pot Metal‐Free Oxidative Cyclization Applicable to Various Substrates (Asian J. Org. Chem. 8/2013)(2013)