A Microwave-Assisted Diastereoselective Multicomponent Reaction To Access Dibenzo[c,e]azepinones: Synthesis and Biological Evaluation
The Journal of Organic Chemistry2011Vol. 76(8), pp. 2828–2839
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Vaibhav P. Mehta, Sachin G. Modha, Eelco Ruijter, Kristof Van Hecke, Luc Van Meervelt, Christophe Pannecouque, Jan Balzarini, Romano V. A. Orrù, Erik V. Van der Eycken
Abstract
An unprecedented microwave-assisted multicomponent strategy has been elaborated for the fast, efficient, and diastereoselective generation of the dibenzo[c,e]azepinone scaffold. The generated compounds were evaluated for their bioactivity.
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