Copper-Catalyzed Direct Oxidative C–H Amination of Benzoxazoles with Formamides or Secondary Amines under Mild Conditions
The Journal of Organic Chemistry2011Vol. 76(13), pp. 5444–5449
Citations Over TimeTop 10% of 2011 papers
Abstract
A facile, efficient, and practical method for copper-catalyzed direct C-H amination of benzoxazoles with formamides or secondary amines has been developed. The system can be performed in the absence of external base and only requires O(2) or even air as oxidant. A variety of substituted benzoxazol-2-amines were synthesized with moderate to excellent yield.
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