Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C
The Journal of Organic Chemistry2011Vol. 76(17), pp. 7281–7286
Citations Over TimeTop 10% of 2011 papers
Abstract
The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 °C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl β-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.
Related Papers
- → Kinetic Resolution and Chemoenzymatic Dynamic Kinetic Resolution of Functionalized γ-Hydroxy Amides(2005)47 cited
- → Dynamic kinetic resolution of γ-hydroxy acid derivatives(2002)63 cited
- → Enantioselective Acylation of 3-Hydroxyphthalides by Pyrrolomidazole-Catalyzed Dynamic Kinetic Resolution(2020)
- → Dynamic Kinetic Resolution of Racemic 2-Substituted Indoles by Pd-Catalyzed Asymmetric Hydrogenation(2024)
- Kinetic resolution strategies(1992)