Synthesis of the Thiazole–Thiazoline Fragment of Largazole Analogues
The Journal of Organic Chemistry2011Vol. 76(23), pp. 9845–9851
Citations Over TimeTop 23% of 2011 papers
Abstract
The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.
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