Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles by a Sequential Aza-Wittig/Michael/Isomerization Reaction
The Journal of Organic Chemistry2011Vol. 77(1), pp. 696–700
Citations Over TimeTop 10% of 2011 papers
Abstract
Carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aryl isocyanates, reacted with secondary amines in the presence of a catalytic amount of sodium alkoxide to give 1,2,4,5-tetrasubstituted imidazoles 7 in good yields. However, 4-acylimidazoles 11 were obtained, as phenols were used in the presence of a catalytic amount of potassium carbonate due to further air oxidation of the expected products 10.
Related Papers
- → Mechanistic Insights into the Post‐Cyclization Isomerization in Gold‐Catalyzed 7‐exo‐dig‐Hydroarylations(2015)38 cited
- → Isomerization reactions of n-hexane on partially reduced MoO3/TiO2(2007)33 cited
- → Anisatinic acid and isoanisatinic acid, isomerization products of anisatin(1968)10 cited
- → Novel insight into the photochemical cis-trans isomerization of olefins.(1986)10 cited
- → Isomerization(2017)