Asymmetric Michael Addition of α-Substituted Isocyanoacetates with Maleimides Catalyzed by Chiral Tertiary Amine Thiourea
The Journal of Organic Chemistry2012Vol. 77(6), pp. 2947–2953
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Jian‐Fei Bai, Liang‐Liang Wang, Lin Peng, Yunlong Guo, Lina Jia, Fang Tian, Guangyun He, Xiao‐Ying Xu, Lixin Wang
Abstract
A highly diastereoselective and enantioselective Michael addition of α-substituted isocyanoacetates with maleimides catalyzed by bifunctional tertiary amine thioureas has been developed. Various chiral succinimide derivatives bearing adjacent quaternary and tertiary stereocenters were prepared in excellent yields (up to 98%), diastereoselectivities (up to 99:1), and enantioselectivities (up to 98% ee). The synthetic utility of chiral succinimide derivatives is also demonstrated in the preparation of h5-HT(1d) receptor agonist motifs.
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