Palladium-Catalyzed Ortho-Arylation of Benzamides via Direct sp2 C–H Bond Activation
The Journal of Organic Chemistry2012Vol. 77(7), pp. 3341–3347
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Abstract
The palladium-catalyzed ortho-arylation of benzamides by aryl iodides has been demonstrated with the simplest amide CONH(2) as a directing group for the first time. This protocol can be applied to various benzamides and aryl iodides with both electron-donating and electron-withdrawing groups. In addition, the synthesized biphenyl-2-carboxamides can be further transformed to other biphenyl derivatives such as nitriles, carboxylic acids, carbamates, and amines.
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