Cooperative Catalysis Approach to Intramolecular Hydroacylation
The Journal of Organic Chemistry2012Vol. 77(14), pp. 5884–5893
Citations Over TimeTop 11% of 2012 papers
Abstract
Prior examples of hydroacylation to form six- and seven-membered ring ketones require either embedded chelating groups or other substrate design strategies to circumvent competitive aldehyde decarbonylation. A cooperative catalysis strategy enabled intramolecular hydroacylation of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded chelating groups.
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